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產(chǎn)品詳細頁Rho-conotoxin TIA (Rho -芋螺毒素TIA )
簡要描述:Smartox Biotechnology是*一家專門生產(chǎn)動物毒液多肽毒素,用于細胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價值。
- 產(chǎn)品型號:CON022
- 廠商性質(zhì):代理商
- 更新時間:2024-10-30
- 訪 問 量:1839
產(chǎn)品介紹
Rho-conotoxin TIA (Rho -芋螺毒素TIA )
Blocker of α1-adrenoreceptor(腎上腺素受體α1阻斷劑)
Rho-conotoxin TIA has been isolated from the venom of the fish-hunting marine cone snail Conus tulipa. Rho-conotoxin TIA is a selective antagonist of α1-adrenoreceptor (α1A-, α1B- and α1D-AR). It acts non-competitively ontoα1B-adrenoreceptor but competitively on α1A-adrenoreceptor and α1D-adrenoreceptor. The most important residue for activity is Arg4. Rho-conotoxin TIA is 10-fold selective for human α1B-adrenoreceptor over
α1A-adrenoreceptor and α1D-adrenoreceptor. The IC50 values for Rho-conotoxin TIA for inhibition of 125I-BE were 18 nM for human α1A-AR, 2 nM for α1B-AR and 25 nM for α1D-AR.
Rho-conotoxin TIA 技術(shù)資料
氨基酸序列:Phe-Asn-Trp-Arg-Cys5-Cys6-Leu-Ile-Pro-Ala-Cys11-Arg-Arg-Asn-His-Lys-Lys-Phe-Cys19-NH2
二硫鍵: Cys5-Cys11 and Cys6-Cys19
長度 (aa):19
分子式:C105H160N36O21S4
分子量: 2390.90 Da
外觀: White lyophilized solid
可溶性:aqueous buffer
CAS 號: not available
來源: Synthetic
純度:> 97 %
產(chǎn)品信息
CON022-00100 | Rho-conotoxin TIA | 0.1mg |
CON022-00500 | Rho-conotoxin TIA | 0.5mg |
CON022-01000 | Rho-conotoxin TIA | 1mg |