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Huwentoxin-IV（虎紋捕鳥蛛神經(jīng)毒素-IV）
簡要描述：Smartox Biotechnology是*一家專門生產(chǎn)動物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價值。
產(chǎn)品型號：08HWT002- 廠商性質(zhì)：代理商
- 更新時間：2024-10-29
- 訪 問 量：1939
產(chǎn)品介紹
Huwentoxin-IV（虎紋捕鳥蛛神經(jīng)毒素-IV）
TTX-S selective blocker(電壓門控鈉離子通道TTX-S選擇性阻斷劑)
Huwentoxin IV (HwTx-IV) is a neurotoxin that was originally isolated from Haplopelma schmidti (Chinese bird spider). This lethal neurotoxin acts selectively on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with an IC50 of 30 nM in rat DRG neurons. It preferentially inhibits neuronal voltage-gated sodium channel subtype hNav1.7 (SCN9A, IC50 is 26 nM), rNav1.2 (SCN2A, IC50 is 150 nM), and rNav1.3 (SCN3A, IC50 is 338 nM), compared with muscle subtypes rNav1.4 (SCN4A) and hNav1.5 (SCN5A) (IC50 is > 10 µM).Huwentoxin IV inhibits the activation of sodium channels by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration.
Huwentoxin-IV（虎紋捕鳥蛛神經(jīng)毒素-IV）技術(shù)資料
氨基酸序列：
Glu-Cys2-Leu-Glu-Ile-Phe-Lys-Ala-Cys9-Asn-Pro-Ser-Asn-Asp-Gln-Cys16-Cys17-Lys-Ser-Ser-Lys-Leu-Val-Cys24-Ser-Arg-Lys-Thr-Arg-Trp-Cys31-Lys-Tyr-Gln-Ile-NH2
二硫鍵：Cys2-Cys17, Cys9-Cys24 and Cys16-Cys31
長度 (aa)：35
分子式：C174H277N51O52S6
分子量：4109.18 Da
外觀：White lyophilized solid
可溶性： water and saline buffer
CAS 號：not available
來源：Synthetic
純度：> 97 %
產(chǎn)品信息
08HWT002-00100 | Huwentoxin IV | 0.1mg |
08HWT002-00500 | Huwentoxin IV | 0.5mg |
08HWT002-01000 | Huwentoxin IV | 1mg |
